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Perdita vs. smarrimento

The Italian words perdita and smarrimento both translate to the English word loss, but they are used in very different contexts. The word perdita generally indicates a permanent deprivation, a financial deficit, or the passing away of a person. On the other hand, smarrimento refers to misplacing a physical object, often with the hope of finding it, or describes a psychological feeling of confusion and disorientation.

Perdita

The word perdita refers to a permanent or irreversible loss. It is the correct word to use when talking about the death of a loved one, financial and economic deficits, the waste of abstract concepts like time or patience, and even physical leaks of gas or water.
La sua improvvisa morte è stata una grande perdita per tutta la comunità.
(His sudden death was a great loss for the whole community.)
L'azienda ha subito una grave perdita economica durante l'ultimo trimestre.
(The company suffered a severe financial loss during the last quarter.)
Discutere con una persona così testarda è solo una perdita di tempo.
(Arguing with such a stubborn person is just a waste of time.)
L'idraulico deve intervenire urgentemente per riparare una perdita d'acqua nel bagno.
(The plumber needs to intervene urgently to fix a water leak in the bathroom.)
Il forte trauma cranico gli ha causato una temporanea perdita di memoria.
(The severe head trauma caused him a temporary loss of memory.)

Smarrimento

The word smarrimento is used to describe the act of misplacing a physical object or a pet, often implying that the item could potentially be found again. Additionally, it is frequently used to describe an emotional or psychological state of bewilderment, confusion, and feeling completely lost.
Ho dovuto denunciare immediatamente alla polizia lo smarrimento del mio passaporto.
(I had to report the loss of my passport to the police immediately.)
I passeggeri possono rivolgersi all'ufficio smarrimento bagagli al piano terra dell'aeroporto.
(Passengers can go to the lost luggage office on the ground floor of the airport.)
Abbiamo stampato dei volantini colorati per segnalare lo smarrimento del nostro cane.
(We printed some colorful flyers to report the loss of our dog.)
Dopo aver ricevuto quella strana notizia, ha provato un profondo senso di smarrimento.
(After receiving that strange news, he felt a deep sense of bewilderment.)
Il suo sguardo rivelava un totale smarrimento di fronte a tutte quelle nuove responsabilità.
(His gaze revealed total disorientation in the face of all those new responsibilities.)

Summary

In summary, you should use perdita for permanent and irreversible losses, financial deficits, abstract waste, or physical leaks. You should choose smarrimento when dealing with misplaced physical items and pets, or to express an emotional state of feeling lost, bewildered, and confused.